【摘要】 目的：探讨胃泌素在人体内与大肠癌生长的关系、作用及其临床意义。方法：用放免法测定43例行根治术大肠癌病人空腹血清、癌组织及癌旁粘膜。结果：大肠癌病人血清胃泌素水平明显高于正常对照组（P＜0．05），行根治术后胃泌素水平明显下降（P＜0．05），血清胃泌素水平与大肠癌组织学类型相关，大肠癌组织及癌旁粘膜中胃泌素水平明显增高（P＜0．05）。结论：进一步认识了大肠癌的生物学特性，人体内大肠癌细胞的生长受到胃泌素的调控，胃泌素水平的测定可提供选择大肠癌病人行激素治疗的辅助指标。更多还原

【Abstract】 Objective: To study the role and clinical significance of gastrins (G) in the progression and adjunct treatment of large intestin carcinoma (LIC). Methods: G concentratiion in fasting blood, cancer tissues and its adjacent mucosas sampled from 43 pathernts with LIC were measured by radio inununoassay.Result: Fasting G levels in patients with LIC were sigmficantly higher than the normal surum controls (P<0.05), and decreased to normal value after resection of cancer. Surum G level were correlated with differentiation types of cancer. The cancer tissues and its adjacent mucosas cantained high levels of G than the normal mucosas (P<0.05). Conclusions:The grawth of LIC in vivo were regulated by G and G level might be an indicative parametes for selections of patients with LIC to be treated with hormonothesapy and study of bialogical character of LIC.更多还原