【摘要】 目的：探讨胎儿生长迟缓（ＩＵＧＲ）与抗心磷脂抗体（ＡＣＡ）的相关性。方法：用酶联免疫吸附法检测５３３０例正常孕妇血清的ＡＣＡ。同时对ＩＵＧＲ合并ＡＣＡ阳性产妇产后胎盘进行免疫荧光检查，了解其结构改变。结果：正常孕妇ＡＣＡ阳性发生率为２．７０％，其中ＩＵＧＲ发生率１５．２８％，ＡＣＡ阴性的孕妇ＩＵＧＲ发生率为１．７７％，两者比较，差异有极显著性（Ｐ＜０．００１）。新生儿ＡＣＡＩｇＧ阳性５例，胎盘免疫荧光检查发现胎盘组织均出现免疫球蛋白荧光抗体和补体阳性着色。结论：ＡＣＡ阳性是ＩＵＧＲ发生的病因之一，ＡＣＡ检测给ＩＵＧＲ的病因诊治提供了新的研究途径。更多还原

【Abstract】 Objective: To investigate the relationship between fetal intrauterine growth retardation and anticardiolipin antibodies. Methods: Serum anticardiolipin antibodies were detected with ELISA method in 5 330 cases of normal gravidas. Meanwhile, the observation of immunocomplex depositions in placentas in cases of positive anticardiolipin antibodies (ACA) were observed by immunofluorescence examination. Results: The positive ACA rate in normal gravidas was 2.70%. The incidence of intrauterine growth retardation (IUGR) was 15.28% in cases of positive ACA, wherease was 1.77% in cases of negative ACA. There were significant differences between two groups ( P <0.001). Among children born in mothers with positive ACA, there were 5 cases of positive ACA. Immunocomplex depositions (Immunoglobulins & Complements) were all found in placenta of IUGR. Conclusions: ACA could be one of causes for IUGR. Determination of serum ACA would offer a new clue to diagnosis and treatment of IUGR.更多还原