【摘要】 目的：探讨重型颅脑损伤后高钠血症的病因、发生机制及其病理生理和治疗．方法：分析近年收治的４０例重型颅脑损伤病人的临床资料，记录血钾、钠、氯的测定值和液体出入量，并对所得结果进行统计学处理．结果：高钠血症与病人的年龄、ＧＣＳ和血氯水平关系密切（与年龄、ＧＣＳ呈负相关，与血氯水平呈正相关）．结论：严重颅脑损伤时抗利尿激素（ＡＤＨ）分泌减少和血中糖皮质激素的增高可能是发生非低容量性高钠血症的主要机制．而年龄因素则与颅脑损伤多见于年龄较轻者及因肾和垂体后叶的生理特点而少见于年长者有关．钠、氯在代谢中有相互伴随关系，因此血氯增高在高钠血症时临床意义不大更多还原

【Abstract】 Aim: To approach the causes, mechanism, pathophysiology, and managements of hypernatremia after severe head injury. Methods: Clinical materials, values of blood potassium, natrium, chloremia, water intaking, glucocorticosteroid (GCS), and glucose oligosac charide (GOS) were analyzed on 40 patients with severe head injury. And some statistical processes were performed. Results: Hypernatremia is closely related to the age of patients, GCS and value of chloremia (negative correlation with age and GCS, and positive correlation with chloremia). Conclusion: The increase of antidiuretic hormone (ADH) and adrenocorticotropic hormone (ACTH) in blood is considered after severe head injury.更多还原