【摘要】 采用跳台和避暗法实验对益智丸进行研究，结果表明益智丸１００ｍｇ／ｋｇ连续ｉｇ给药１５天，能明显促进正常小鼠的记忆功能；１００，２００，５００ｍｇ／ｋｇ连续ｉｇ给药５天，能明显对抗东莨菪碱、亚硝酸钠及乙醇引起的记忆障碍；２００，５００ｍｇ／ｋｇ连续ｉｇ给药４１天，明显改善Ｄ半乳糖所致的亚急性衰老小鼠的记忆损害，并升高其脑内ＳＯＤ活力，降低ＭＤＡ含量，抑制其胸腺指数的下降；另外，益智丸还能升高环磷酰胺诱导的免疫低下小鼠炭粒廓清指数及溶血素抗体生成量，增强氢化泼尼松抑制的细胞免疫反应。更多还原

【Abstract】 Passive avoidance tests have shown that Yizhi Pills (YZ) markedly improve the memory of normal mice at a dose of 100mg/kg after oral administration for fifteen days,and significantly reverse the scopolamine,NaNO 2 and EtOH induced disruptions of memory retention in mice at doses of 100,200,500mg/kg after oral administration for five days.In aged mice induced by D galactose,YZ also significantly improve the impaired memory,increase the activity of SOD and decrease the content of MDA in brain.All these effects were observed at doses of 200,500mg/kg after oral administration for forty one days.YZ significantly promote blood carbon particle clearance,enhance hemolysin antibody in immunodepressed mice induced by cyclophosphamide,and increase earswelling in immunodepressed mice induced by prednisolonum.更多还原