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承气合剂对小鼠腹腔巨噬细胞合成释放IL-6和TNF的量效关系及合理用药

The DoseDependent Relationship between Chengqi Mixture and IL6/TNF Released from Peritoneal Macrophages in Mice

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【作者】 王宏镛翁福海李会强姚智

【Author】 Wang Hongyong ,et al Department of Pharmacology,Tianjin Medical University(300070)

【机构】 天津医科大学

【摘要】 本实验通过体外细胞培养[1]观察了承气合剂在0.0625%~1%系列浓度下,对小鼠腹腔巨噬细胞(macrophage,MΦ)释放肿瘤坏死因子(tumornecrosisfactor,TNF)和白介素6(interleukin-6,IL-6)的影响,发现随着“合剂”浓度递增IL-6的释放量增加,以中剂量组释放量最高。TNF的释放量在合剂0.0625%浓度时即已完全抑制,未能检出;同时观察了在内毒素(lypopolysaccharide,LPS)诱导下,承气合剂系列浓度对MΦ分泌上述二因子的影响,随着“合剂”浓度递增,IL-6及TNF的释放量减少,呈量效关系。

【Abstract】 hengqi mixture(承气合剂CQM)promoted the synthesis of interleukin (IL6) and tumor necrosis of factor(TNF) released form normal peritoneal M significantly while fhey were inhibited both IL6 form normal peritoneal macrophage(M) in mice,but inbibited both IL6 and TNF released from M significantly while fhey were induced by LPS in vitro.There was a dosedependent relationship between the dose of CQM in the range of 0.0625%and the amount of IL6/TNF released from M.

  • 【文献出处】 中国中西医结合外科杂志 ,CHINESE JOURNAL OF SURGERY OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE , 编辑部邮箱 ,1997年06期
  • 【分类号】R-332
  • 【被引频次】13
  • 【下载频次】42
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