The endotoxin,XOD,GSH,MDA,TNF,GPT and hepatic pathological change were observed as indices for analysing the effects of Fu an disperser on liver and endotoxaemia in experimental peritonitis of rats. The results showed that the levels of endotoxin in peripheral and portal veins were significantly reduced with the treatment of Fu an disperser.The release of TNF was also inhibited and the liver was protected from lipoperoxide injury.