【摘要】 通过对慢性阻塞性肺病患者（ＣＯＰＤ）骨代谢指标的观察，并与正常人作统计比较，以了解长期慢性缺氧等因素是否会造成ＣＯＰＤ患者骨质疏松，从而在临床工作中给予预防性治疗。方法按性别分组测定ＣＯＰＤ患者（男１６例，女１３例）血清Ｃａ、Ｐ水平，放免法测定血清骨钙素（ＢＧＰ）、酶联免疫吸附法测定晨尿脱氧吡啶酚（ＤｐＤ），同时测定股骨Ｎｅｃｋ、ｗａｒｄ＇ｓ和Ｔｒｏｃｈ三个部位的骨密度（ＢＭＤ）。对上述结果进行同年龄段成对数据单尾ｔ检验。结果ＣＯＰＤ组血Ｃａ、血Ｐ水平较正常组无明显差异；观察组血清ＢＧＰ较正常组升高（男３１％，女４０％，Ｐ＜０．０５）；ＣＯＰＤ组的ＤｐＤ水平比正常组显著升高（男１４４％，女１５６％，Ｐ＜０．０１）；ＣＯＰＤ组的ＢＭＤ值降低，男性均值为正常的６９．８％，女性为７２．５％（Ｐ＜０．０１）。结论ＣＯＰＤ患者的骨形成与骨吸收均增高，但骨吸收程度大于骨形成，最终导致患者骨量减少，引发骨质疏松。临床工作中对这类患者除治疗原发病、纠正低血氧外，可预防性地补充钙及ＶｉｔＤ，避免骨质疏松，提高患者生活质量。更多还原

【Abstract】 In this study 29 patients with chronic obstructive pulmonary diseases (COPD including chronic bronchitis and bronchial asthma) were divided into two groups by sex (13 males and 16 females).Sensitive indices,such as serum osteocalcin(BGP),urinary deoxypyridoxine (DPD) and bone mineral density(BMD), were determined in each case, and compared with corresponding control group, respectively. Both the measured results and statistical tests indicated that BMD levels in COPD patients were much lower than those in normal people, and patients’ DpD values were higher than those in the control groups. On the other hand,there is no statistacally significant difference in BGP index. Based on our observations,it is suggested that long-term chronic hypoxia in COPD patients may lead to abnormal changes in bone metabolism and marked increase in bone absorption,causing reduction of BMD and tendency of osteoporosis,which deserves much attention in clinical treatment.更多还原