【摘要】 本文为了解瘤内直接注射90Y－GTMS后，瘤内吸收剂量的分布及相应的生物效应，采用昆明鼠，腋下接种S18肿瘤细胞，8天后在注射部位长成实体瘤块。21只带瘤鼠，分成3组。分别向瘤块中心注射不同剂量的90Y－GTMS碘油悬浮液50μl，在注射点周围不同距离理放热释光探测元件测定其吸收剂量。病理实验组，58只带瘤鼠，10只作为对照组，其中每12只为一个剂量组，分别向各组瘤内注射同体积，不同剂量的90Y-GTMS。在注射后的不同时间分批杀死各剂量组小鼠观察病理变化。结果示大部分吸收剂量集中在距注射点5mm以内，在此范围内，吸收剂量随点源剂量增长而增长，超过此范围，吸收剂量变化不显著。病理结果显示90Y－GTMS的有效杀伤半径为4～5mm，有效杀伤半径不随剂量的增加而增大。更多还原

【Abstract】 To clarify the doses absorbed around the radloactlve source and its corresponding biological effect after intratumoral injection of 90Y GTMS Kunming mice were inoculated subcutaneously with S180 tumor cells. In 8 days, solid tumor grew at the injection site. Twenty one rnice were killed and the tumor bulks were taken out, into the center of which 90T-GTMS was injected. The thermoluminescence dosimeters sensor parts were implanted at varlous points of different dis tance away from the injection slte to measure the intratumoral distribution of the doses absorbed. Another 58 mice were dlvlded into 5 groups (1 as control group, 4test groups ). The 90Y-GTMS was inJected into the turnor center of those of the test groups with different doses, and on the 3rd, 7th, 14th day after injection 58 mice were killed for pathological examination. Results: 1) Most of the absorbed doses were within the range of 5mm and were minimal beyond; 2) The biggest lethal dosage radius of 90 Y-GTMS was no further than 4~5mm. The lethal dosage radius did not increase with the increase of injected doses.更多还原