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当归对环磷酰胺的增效作用
Synergistic effect of angelica sinensis on CTX in treating transplanted tumors of mice
【摘要】 采用不同药物对移植瘤鼠进行治疗,结果表明单用当归、环磷酰胺的小鼠血、瘤组织中层粘蛋白(LN)、DNA聚合酶(DNA-P)与生理盐水对照组比较,无明显变化,而当归合并环磷酰胺(CTX)则使鼠血、组织LN、DNA-P显著降低(P<0.01)。血超氧化物歧化酶(SOD)活性显著增高(P<0.01)。提示当归合并CTX治疗实验性肿瘤比单用当归、CTX效果好。当归有一定的增强CTX疗效作用。
【Abstract】 In this study, Danggui(angelica root, angelica sinensis) or/and CTX was used to treat the mice with transplanted tumors and determin the levels of LN and DNA P in their blood and tissues. The results showed that in comparison with the control group, there was no differences from using angelica sinensis and CTX separately. But a significant decrease of LN and DNA P( P < 0.01 ) and a remarkable increase of SOD ( P < 0.01 ) could be observed in the group of using both angelica sinensis and CTX. It indicates that the therapeutic effect is better in the combined group than that in angelica sinensis or CTX group, and angelica sinensis has a synergistic effect on CTX in tumor treatment.
【Key words】 Angelica root; cyclophosphomide(CTX); laminin(LN); superoxide dismitutase(SOD); DNA polymerase(DNA P);
- 【文献出处】 中国医院药学杂志 ,CHINESE JOURNAL OF HOSPITAL PHARMACY , 编辑部邮箱 ,1997年07期
- 【分类号】R285.6
- 【被引频次】6
- 【下载频次】51