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胸腔内注射阿霉素治疗恶性胸腔积液的药物浓度监测和药效学研究
The therapeutic drug monitoring and pharmacodynamic study on intrapleural adriamycin in malignant effusions patients
【摘要】 以荧光光谱法对胸腔内注射国产阿霉素治疗恶性胸腔积液患者的血液、胸水中的药浓度进行监测和药效对比研究。研究表明:胸腔内注射40mg阿霉素后,9例患者2h的平均血、胸水药浓度分别为65ng/ml,59μg/ml,比值为1∶829,其它时间的胸水药浓度高于相同时间的血药浓度数百倍(P<0.05)。在12例的疗效评价中,显效率33.3%,有效率50%,未发生骨髓抑制、心肌损害等严重毒副反应。
【Abstract】 he drug concentration monitroring (TDM) and pharmacodynamic study on intrapleural adriamycin in malignant effusions patients wrer reported.After 40mg adriamycin was administered intrapleurally,the mean adriamycin level of plasma and effusion,measured by spectrofluorometry seperately,were 65.3 ng/ml and 58.6 μg/ml at 2h,the ratio was 1/827.The results showed that the drug concentration of the effusion was much higher than that of the plasma in 48h ( P < 0.05 ).Of 12 patients treated with this manner, 33.3% and 50% achieved “remarkable response” and “response” respectively,and no myelosuppression or cardiotoxicity were seen.On the basis of the above TDM and pharmacodynamic study,the chief advantage of intrapleural treatment in patients with malignant effusions is the higher local drug concentration,and the avoidance of systemic toxic effects.
【Key words】 therapeutic drug monitoring (TDM); pharmacodynamics; intrapleural adriamycin malignant effusion;
- 【文献出处】 中国医院药学杂志 ,CHINESE JOURNAL OF HOSPITAL PHARMACY , 编辑部邮箱 ,1997年04期
- 【分类号】R730.53
- 【被引频次】6
- 【下载频次】56