【摘要】 目的：制取２０（Ｓ）原人参二醇组皂苷并将其转化制备抗癌活性单体２０（Ｓ）人参皂苷Ｒｈ２。方法：以国产西洋参茎叶总皂苷为原料，通过萃取法制备２０（Ｓ）原人参二醇组皂苷；将２０（Ｓ）原人参二醇组皂苷碱催化水解后，经柱层析分离纯化制备２０（Ｓ）人参皂苷Ｒｈ２。结果：２０（Ｓ）原人参二醇组皂苷收率为４１．５％，其转化成２０（Ｓ）人参皂苷Ｒｈ２的转化率为９．６４％。结论：制取方法简便，收率较高。更多还原

【Abstract】 OBJECTIVE: To prepare 20(S) protopanaxadiol saponins and change them into 20(S) ginsenoside Rh 2 having antitumor activity. METHODS: From the crude saponins of the stems and leaves of American ginseng grown in China, we prepared 20(S) protopanaxadiol saponins by extraction and 20(S) ginsenosiok Rh 2 by the alkaline hydrolysis of protopanaxadiol saponins and column chromatography. RESULTS: The yield of 20(S) protopanaxadiol saponins was 41.5%, and the yield of 20(S) ginsenoside Rh 2 was 9.64% from the 20(S) protopanaxadiol saponins.CONCLUSION: The method is simple and has a high yield.更多还原