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抗心律失常药盐酸索他洛尔的合成
Synthesis of Anti-arrhythymic Sotalol
【摘要】 以苯胺为原料,经甲磺酰氯的酰化反应,溴乙酰溴的傅克酰化反应和异丙胺的分子间亲核取代反应及还原四步合成盐酸索他洛尔。经工艺改进,各步收率均有较大的提高,总收率达44.83%。
【Abstract】 Starting from aniline, and undergoing mesylation, Friedel-Crafts acylation, isopropylami-nation and hydrogenation, sotalol hydrochloride was synthesized. The yields of every step were promoted by modifying the reacting conditions. The total yield reaches 44. 83%.
【关键词】 抗心律失常药;
盐酸索他洛尔;
合成;
β-阻滞剂;
【Key words】 Anti-arrhythymic; Sotalol hydrochloride; Sythesis; β-blocker;
【Key words】 Anti-arrhythymic; Sotalol hydrochloride; Sythesis; β-blocker;
- 【文献出处】 中国药科大学学报 ,Journal of China Pharmaceutical University , 编辑部邮箱 ,1997年03期
- 【分类号】R914
- 【被引频次】3
- 【下载频次】375