【摘要】 为了评价改良的校正ＱＴ间期（ＱＴＬＣ）方法的准确性和临床实用价值，选取７２例健康成人，采用踏车运动试验逐步提高心率（ＨＲ），于ＨＲ每增加１０ｂｐｍ描记一次监测导联心电图，测定ＲＲ及ＱＴ间期，计算ＱＴｃ、ＱＴＬＣ［ＱＴＬＣ＝ＱＴ＋０．１５４（１－ＲＲ）］。发现当ＨＲ＜１２０ｂｐｍ时ＱＴｃ与ＨＲ呈显著正相关（ｒ＝０．８５，Ｐ＜０．００２）；ＨＲ＞１２０ｂｐｍ时ＱＴｃ与ＨＲ呈显著负相关（ｒ＝－０．８７，Ｐ＜０．００５）。ＨＲ在６０～１００ｂｐｍ之间时ＱＴＬＣ基本恒定，与ＨＲ无相关关系（ｒ＝－０．１９，Ｐ＞０．０５）；ＨＲ＞１００ｂｐｍ时，ＱＴＬＣ与ＨＲ呈显著负相关（ｒ＝－０．９１，Ｐ＜０．００１）。结果提示：在ＨＲ正常的前提下，ＱＴＬＣ基本不受ＨＲ影响，因而ＱＴＬＣ用于监测抗心律失常药物对心室肌电活动的影响、预测ＱＴ间期延长所致恶性心律失常及猝死等心脏事件，其准确性及临床实用价值似应优于ＱＴｃ。更多还原

【Abstract】 To determine the clinical evaluation of a new correct formula for QT interval,72 healthy adults were examined with the pedal stress.The monitor ECG was recorded during the exercise.The QTc was calculated with Bazetts formula.The QT LC was calculated with the new correct formula QT LC =QT+0.154(1-RR) .The results showed QTc was positively correlated with the heart rate (HR) when the HR was less than 120 beat perminute (bpm) ( r =0.85, P <0.002),but negatively correlated with the HR when the HR was more than 120 bpm ( r = -0.81 , P <0.005);QT LC was not correlated with the HR when the HR was from 60 to 100 bpm( r =-0.19, P >0.05),but negatively correlated the HR when the HR was more than 100 bpm ( r =-0.91, P <0.001).These results suggest that QT LC is more accurate than QTc for correcting the QT interval when the HR is at normal range (from 60 to 100 bpm).And QT LC is better than QTc for forecasting the malignant arrhythmia and sudden death,which are caused by the length QT interval.更多还原