【摘要】 32例 NIDDM 和13例原发性高血压患者服依那普利(10mg,Bid)共3天,服药前后测定24小时动态血压和尿白蛋白(UAER)、转铁蛋白(UTER)、视黄醇结合蛋白(URER)排泄率。服药3天后,NIDDM 的24小时动态血压和尿蛋白排泄率明显下降;在原发性高血压患者,夜间 SBP 除外,依那普利并未能使24小时动态血压明显减低,但全天及白天、夜间的 UAER 明显降低。本研究认为依那普利对肾脏有特殊的保护作用,而这一作用不单纯依赖于血压的降低。更多还原

【Abstract】 The acute therapeutic effect of enalapril,an angiotensin converting enzyme inhibitor (ACEI),in reducing blood pressure and urinary albumin excretion rate(UAER) were assessed in 32 NID- DM and 13 essential hypertensive patients.After treatment for three days,24-h blood pressure and UAER in NIDDM patients were reduced significantly.UAER of essential hypertensive patients were reduced while in hypertensive patients UAER were reduced,but blood pressure except night SBP remained unchanged. This study suggests enalapril may have a specific protect effect on kidney which is independent of the de- crease in systemic blood pressure.更多还原