【摘要】 本实验建立了清醒无拘束豚鼠气道反应性的测定方法，具有简便、稳定、可定量研究的特点。清醒豚鼠吸入组胺（Ｈｉｓ）和乙酰胆碱（ＡＣｈ）后的引喘作用有浓度依赖性，半数有效引喘浓度（ＥＣ５０）分别为５３．５μｍｏｌ／ｍ３和２６９μｍｏｌ／ｍ３。更多还原

【Abstract】 A simple,stable determining system in the conscious and unrestrained guinea pigs was established that can quantitatively analyse the airway reactivity (AR).In this model,the response to histamine (His) or acetylcholine (ACh) aerosol was concentration dependent with EC 50 effective concentration causing 50% animals wheezing) of 53.3μmol/m 3 and 269μmol/m 3 respectively.更多还原