【摘要】 本实验制作了尖端的直径为０５－５０μｍ和斜面为２５°的玻璃微插管，成功地建立了用显微穿刺（ｍｉｃｒｏｐｕｎｃｔｕｒｅ）技术直接测量微血管压力（Ｐｍ）的伺服零方法（ｓｅｒｖｏｎｕｌｍｅｔｈｏｄ），对自发高血压大鼠（ＳＨＲ）和正常血压大鼠（ＷＫＹ）肠系膜Ｐｍ进行了测量研究。结果表明，ＳＨＲ的平均动脉压（ＰＡ）和微动脉的Ｐｍ均明显大于ＷＫＹ的ＰＡ和Ｐｍ；ＰＡ在微动脉中明显降低，最大压降在直径小于５０μｍ的微动脉以及毛细血管中。更多还原

【Abstract】 The dynamic microvascular pressures in the mesentery of spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats were measured and recorded by using the Servo null microvascular pressure measuring system (Model 4A,IPM,Inc.,San Diego,USA) with glass micropipettes whose tips were 1.0-5.0μm in diameter and had been beveled very sharply at an angle of 25 degree.Microvascular pressures were measured in two groups of microvessels:large,25-45 μm;small,15-25μm.Mean microvascular pressures (Pm) of large and small arterial microvessels in SHR were 6.0±7.0 kPa and 4.8±0.6 kPa,respectively.In WKY rats,Pm were 4.2±0.6kPa and 3.6±0.6kPa,respectively.Pm of comparable types of arterial microvessels in SHR and WKY rats was significantly different.No significant difference of Pm in small venous vessels was found between SHR and WKY rats.更多还原