【摘要】 目的：研究重组人内皮细胞衍生的白细胞介素－８（ＩＬ８）对失血性休克的作用．方法：大鼠股动脉放血至ＭＡＢＰ５３２ｋＰａ，维持９０ｍｉｎ，复制晚期失血性休克模型．输血后，静脉注射ＩＬ８２５０μｇ·ｋｇ－１．放免法测定血浆ＥＴ１和６ＫＰＧＦ１α含量．结果：给予ＩＬ８后，ＭＡＢＰ显著提高，休克状态改善，２ｈ存活率相应提高；休克晚期血浆ＥＴ１水平比正常明显升高（２１±４ｖｓ８２±１８ｎｇ·Ｌ－１，Ｐ＜００１），血浆６ＫＰＧＦ１α含量明显降低（１０７±１２ｖｓ１５７±１１ｎｇ·Ｌ－１，Ｐ＜００１）．ＩＬ８显著降低血浆ＥＴ１水平（１０±４ｎｇ·Ｌ－１，Ｐ＜００１），提高血浆６ＫＰＧＦ１α含量（３６８±１６ｎｇ·Ｌ－１，Ｐ＜００１）．结论：ＩＬ８具有较好的抗休克作用．更多还原

【Abstract】 AIM: To study the effects of recombinant human endothelial derived interleukin 8 (IL 8) on hemorrhagic shock. METHODS: A profound hemorrhagic shock in rats was produced by exsanguination from femoral artery with mean arterial blood pressure (MABP) maintained at 5 32 kPa for 90 min. After transfusion, IL 8 250 μg·kg -1 was iv injected. Plasma endothelin 1 (ET 1) and 6 ketoprostaglandin F 1α (6 KPGF 1α ) contents were determined with radioimmunoassay. RESULTS: After iv IL 8, the MABP in IL 8 group was elevated obviously ( P <0 01), the rat survial 2 h after infusion was increased ( P <0 05). During profound shock the plasma ET 1 levels were higher (21±4 vs 8 2±1 8 ng·L -1 , P <0 01) and the plasma 6 KPGF 1α contents lower than those in normal rats (107±12 vs 157±11 ng·L -1 , P <0 01). IL 8 remark￣ably reduced the plasma ET 1 levels (10 ±4 ng·L -1 , P <0 01) and enhanced plasma 6 KPGF 1α contents (368±16 ng·L -1 , P <0 01). CONCLUSION: IL 8 has beneficial antishock effects.更多还原