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国产人用狂犬病疫苗免疫后的血清学效果

AN ANALYSIS ON SEROLOGICAL EFFECT AFTER IMMUNIZATION WITH PHKC-RV

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【作者】 郭昕东蔡仿潺刘德荣

【Author】 Guo Xindong Cai Fangchan Liu Derong (Shantou Epidemic Prevention Station of Guangdong Province Shantou, 515031)

【机构】 广东省汕头市卫生防疫站

【摘要】 为了解国产地鼠肾人用狂犬病疫苗免疫后的血清学效果,用间接免疫荧光法检测抗体,观察了疫苗免疫后的抗体阳转率。共检测188人,免前抗体均阴性,狂犬病疫苗5针免疫后,156人阳转,阳转率为82.98%。免后14-18天、4~6周和2~4个月的阳转率依次为74.19%,86.51%和77.42%,5针全程免疫失效者,再增加2针,5人中有4人抗体阳转,说明增加针次能提高免疫效果。

【Abstract】 Using IFA method to observe the serological effect after immunization with primary kidney cell cultured Rabies virus(PHKC-RV),the detected positive seroconversion rate was 82.98%(156/188).In different period after immunization,that was 14-18 days,4-6 weeks and 2-4 months later,the positive seroconversion rate was 74.19%,86.51% and 77.42% respectively,they made no much differences.But there was little difference between seroconversion rate and age or sex or the in jection site.The persons who failed to beimmuned through a whole course of vaccination (5 injections) were revaccinated by two boosted injections of PHKC-RV,4 of the 5 persons were positively seroconverted.It showed that adding injections may raiseimmune effect.

  • 【文献出处】 中国计划免疫 ,CHINESE JOURNAL OF VACCINES AND IMMUNIZATION , 编辑部邮箱 ,1997年04期
  • 【分类号】R512.99
  • 【被引频次】4
  • 【下载频次】32
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