【摘要】 用卫生部武汉生物制品研究所生产的血源加热灭活乙型肝炎（乙肝）疫苗６μｇμｇ和１０μｇ全程免疫３～６岁幼儿，免疫后１个月采血检测，其血清抗－ＨＢｓ阳转率为９８１８％，９８１４％，Ｓ／Ｎ平均值为１０１６６，１１３６９。而每剂含１２μｇ的三步化学灭活血源乙肝疫苗，全程免疫后１个月抗－ＨＢｓ阳转率为９８８１％，Ｓ／Ｎ平均值为７９０９，明显低于加热灭活疫苗６μｇ组（Ｐ＜００５）和１０μｇ组（Ｐ＜００１）。说明加热灭活乙肝疫苗免疫原性更好，且免疫剂量、价格均可降低，这将更有利于在广大农村地区推广使用。本次共观察４１０名３～６岁儿童，接种两种不同灭活方式的血源乙肝疫苗后，仅个别儿童接种部位稍有疼痛感，未见发热及局部红晕反应，全程免疫后１个月检测ＨＢｓＡｇ、抗－ＨＢｃ均阴性，证明两种血源疫苗均安全全可靠。更多还原

【Abstract】 The blood-plasma derived hepatitis B(HB) vaccine produced by our institute was heat inactivated and was used to immunize children of 3-6 years of age with two different dos ages,6μg and 10μg in a whole course immunization.One month after vaccination,the positive seroconversion rates of anti-HBs were 98 18% and 98 14%, the S/N mean value were 101 66 and 113 69 in 6μg chenically inactivated by three steps given at 12μg had a positiversion rate of 98.81% and S/N mean value 79 09 that was significantly lower than S/N of heat inactivated HB vaccine of 6μg group(P<0 05)and 10μg(P<0 01)The results showed that the heat inactivated HB vaccine has a satisfactory immunogenicity,the use of vaccine dosage and the cost are much lower that can be accepted in the large rural areas. In this survey,410 children of 3-6 years old were involved in two kinds of HB vaccination and there were only one or two children felt pain on the inoculated site,no local red swelling emerged.One month after whole course of HB vaccination the HBsAg and anti-HB C were all negative,indicating that these two kinds of blood-plasma derived HB vaccine is safe and reliable.更多还原