【摘要】 本文研究了一定声强下，高强度聚焦超声（HIFU）不同的照射治疗时间和次数对H22肝癌生长的抑制作用，旨在探讨HIFU治疗肿瘤的最适宜照射时间、次数及照射方式。实验结果表明，HIFU照射治疗剂量、治疗方式、次数及间隔时间的变化对其抑制肿瘤生长的生物学效应均有一定的影响。这一发现对于加强HIFU治疗肿瘤的生物学效应，减少组织的创伤性反应等方面均有一定的临床意义。更多还原

【Abstract】 In considering of the optimal conditions of the high intensity focused ultrasound (HIFU) treatment for tumors, we designed this study to investigate the relationship between the HIFU dose and its inhibitive effects on the growth of H22 liver tumor. The HIFU dose was defined by the duration of H22 liver tumor. The HIFU dose was defined by the duration of HIFU application with intensity 1200w/cm2. Seventy-three ICR tumor-bearing mice mere divided into a con. trol group and different HIFU treatment groups, which received extracorporeal single or repeat shots of 5 to 15 seconds under ultrasound guidance. Various parameters were used for assessing the tumor growth and the mice nutritional states. Thedata showed that different doses and time-intervals between the treatments provided different inhibitive effects of the H22 tumor growth.更多还原