【摘要】 本实验首次研究生物组织因素（媒质）对高轼率聚焦超声（HIFU）破坏肝组织的影响。采用国产HIFU样机（1．1MHz）．体外观察其靶区在碘化油或蓖麻油不同媒质存在的温度变化。结果显示：不论在高功率（500W/cm2）和低功率（136W/cm2）超声照射下，碘化油使靶区温度升高显著高于无碘的蓖麻油（P=0．0008和P=0．0004）．提示碘比油与HIFU治疗有协同升温作用。用HIFU（1．1MHz，500W/cm2，20s）照射离体肝组织．发现肝内注射碘化油组靶区温度显著高于注射蓖麻油组（P=0．0239），且前者破坏程度和范围均明显大于后者，提示碘化油配合HIFU治疗肝肿瘤具有潜在的增效、定位和导向作用。更多还原

【Abstract】 Biological medium influencing the high-intensity focused ultrasound(HIFU)tyerapy on ablating the liver tissue was determined in the study,The temperature rising in the focal zone which coezisted with medium of iodized oil or castor oil in vitro was observed.The results showed that HIFU(1.1MHz)combined with iodized oil could produce temerature elevation more highly and rapidly than that of HIFU with castor oil,no matter what HIFUezposed in high power 500W/cm2)or relatively low power (136W/cm2)condition(p=0.0008 and P=0.0004,respectively),indivating that iodized oil could enhance the thermal effect of HIFU therapy in synergism.On the excised liver samples,the temperature rises in the focal zone induced by HIFU(1.1MHz,500W/cm2,20s)also occurred more hiqhly and quickly after injection of iodized oil into the liver than that of injection of castor oil(p=0.0239),and the target liver tissue destroyed revealed more radically and extensively by iodized oil than that by castor oil,suggesting that HIFU combined with iodized oil might have potential funstions of synergism,locating and targeting in the treatment of liver tumour.更多还原