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胸腺因子D对复治肺结核病人免疫指标的影响

Effect of Thymic Factor D on Immune subiects in patients with Retreatment pulmonary Tuberculosis

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【作者】 张金福; 高薇薇; 贾红艳; 高宁;

【Author】 Zhang Jinfu; Gao Weiwei; Jia Hongyan; et al. (Beijing Tuberculosis and Thoracic Tumor Research Institute, 101149)

【机构】 北京结核病、胸部肿瘤研究所; 北京结核病、胸部肿瘤研究所 101149; 101149;

【摘要】 本文应用胸腺因子D加化疗药物治疗复治肺结核30例,并以单纯化疗药物治疗组25例作对照,以观察胸腺因子D对肺结核病人免疫功能的影响及辅助治疗的疗效。结果显示,胸腺因子D加化疗组治疗3个月后,OKT+3、OKT+4、OKT+8细胞百分率。T+4/T+8及NK细胞活性均显著升高,各种免疫球蛋白水平也趋于恢复,与单纯化疗组相比有显著性差异(P<0.01~0.05)。痰菌阴转率(59.3%)也明显高于对照组(44.0%)。提示胸腺因子D辅助治疗肺结核在提高细胞免疫功能方面有一定价值。

【Abstract】 We collected 30 cases of retreated pulmonary tuberculosis treated with Thymic Factor D and chemotherapy as treatment group and 25 cases created only with chemotherapy as controls, to observe influence of Thymic Factor D on immune function and the effect in immune combined therapy, The results indicated that in the treatment group, the per-centape of OKT+3. OKT+4. OKT+8 and activity of Natural killer cells was greatly elevated and immunnoglobin levels became normal after three months of treatment, These had apparent difference with the controls ( P< 0. 01 - 0. 05), Sputum nega-tive in treatment group (59. 3%) were higher than that in the controls (44. 0%). It indicated that was of value to treatment of retreated pulmonary tuberculosis at the aspect of improving cellular immune function.

  • 【文献出处】 中国防痨杂志 ,The Journal of the Chinese Antituberculosis Association , 编辑部邮箱 ,1997年01期
  • 【分类号】R521
  • 【被引频次】12
  • 【下载频次】9
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