【摘要】 用小鼠研究了老年心脏的自由基及对缺氧应激耐受力（Ｔ－ＡＳ）的变化，同时探讨了外源性ＳＯＤＡＴＰ．及四逆汤对老年心脏耐受缺氧应激的影响。结果表明：与青年对照小鼠相比，老年小鼠心脏在缺氧环境下心电活动时间（ＣＥＡＴ）显著缩短，缺氧１５ｍｉｎ内停电率明显上升；提示，老年心脏Ｔ－ＡＳ明显减弱。同时，老年心脏ＯＦＲ浓度增加，ＳＯＤ活性下降，ＭＤＡ含量上升；提示，老年心脏存在异常的自中基反应，这可能是老年心脏Ｔ－ＡＳ下降的内在因素之一。外源性ＳＯＤ可部分增强老年心脏的Ｔ－ＡＳ，但其作用不如ＡＴＰ和四逆汤更多还原

【Abstract】 Effect of aging on heart tolerance toward anoxia stress was studied and posibilities of reinforcing this tolerance by drugs was explored. The . results showed. that. (1 ) Cardioelectric activity time (CEAT) were shortened in aged mioe, and CEA stoped . within 15 min suggested that anoxia tolerance of aged heart was decrcased.(2) Abormal oxy- gen free radical reaction existed in aged heart shown by increased MDA and decreased SOD activity. This might be one of the internal factors that caused the decreased toler- ance of aged heart toward anoxia stress.(3) Exogenous SOD strengthened the tolerance of aged heart patrtially but the effect of SOD is mucb weaker than that of ATP and SD.更多还原