【摘要】 给ＳＤ系幼年大鼠饮水中加入胃癌高发区鱼露和亚硝酸钠，干预组同时加入复合营养素（含β－胡萝卜素，ＶＥ，Ｓｅ及茶多酚），实验期２个月。结果：阳性对照组动物血清ＬＰＯ升高，ＧＳＨ、ＧＳＨ－Ｐｘ活力下降（Ｐ＜０．０５），胃粘膜增生以中度为主，而干预组与正常对照组抗氧化各指标均无明显差别（Ｐ＞０．０５）胃粘膜轻度增生。提示复合营养素对鱼露亚硝酸钠饮水致机体过氧化反应与胃粘膜增生有明显抑制作用。另给昆明种小鼠以３７℃亚硝化３小时的５０％鱼露灌胃，干预组同时加复合营养素灌胃，结果阳性对照组骨髓嗜多染红细胞微核率显著高于生理盐水组（Ｐ＜０．０１），干预组则显著低于阳性组（Ｐ＜０．０５），提示复合营养素可抑制亚硝化鱼露诱导的小鼠骨髓细胞微核率的增高作用。更多还原

【Abstract】 The fish sauce from a high risk area of gastric cancer and nitrite were mixed and given to young rats(SD strain)for 2 months.Meanwhile nutrient compound(containing beta carotene,VE,Se and tea polyphenols)was given to intervention group.The results showed that:in the positive control group,serum lipid peroxidation(LPO)increased,glutathione(GSH)and activities of glutathione peroxidase(GSH Px)decreased(P<0.05),and the degree of gastric mucosae proliferation was dominantly moderate.But there were no obvious differences between intervention group and normal control group in each index of antioxidation(P>0.05).The degree of gastric mucosae proliferation in intervention group was dominantly slight.These suggested that nutrient compound could significantly intervene the peroxidative effect and the gastric mucosae proliferation induced by nitrosated fish sauce.In other experiment,50% fish sauce nitrosated for 3 hours at 37℃ was fed to Kunming mice by stomach gavage,while in intervention group nutrient compound was added.The results showed that the frequency of micronuclei of bone marrow cells in positive control group was remarkably higher than those of normal saline group(P<0.01)and intervention group(P<0.05).This indicated that nutrient compound can inhibit the increasing frequency of micronuclei of bone marrow cells induced by nitrosated fish sauce.更多还原