【摘要】 在以行为学为观察指标（甩尾镇痛和斜板实验）的基础上，用组织学方法探讨大剂量强啡肽Ａ在脊髓水平的致瘫作用与其神经毒作用的关系。结果表明，给大鼠蛛网膜下腔（ｉｔ）注射强啡肽Ａ（１１７）２０ｎｍｏｌ·Ｌ－１，共１０μｌ，给药后５～１０ｍｉｎ即引起大鼠后肢不可逆性瘫痪、甩尾反射被抑制长达４０ｈ以上。大鼠脊髓组织学检查发现，腰、骶段脊髓前角运动神经元大量坏死或严重变性、以腰段损伤最为显著（运动神经元减少８７２％），其次是骶段（减少６９６％），胸段损伤不明显（减少８２％）。更多还原

【Abstract】 Intrathecal( it ) injection of 10 μl of dynorphin A(1 17) 20 nmol·L -1 per rat resulted in irreversible hind limb paralysis and suppression of the tail flick reflex lasting for up to 40 h. The dual effects of dynorphin appeared 5～10 min after the it administration. Histologic examination of the spinal cord in the rats demonstrated dead and/or dying and degenerated motor neurons in the ventral horn located predominately in the lumbar segment(a 87 2% reduction of the number of motor neurons, P <0 01 ) and also in a lesser degree in sacral segment(-69 6%, P <0 05). The thoracic segment was essentially normal(-8 2%, P >0 05).更多还原