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影响炎症免疫反应的药物研究及其思路

Development of the Medicine Acting on Inflammatory Immune Response

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【作者】 徐叔云丁长海魏伟李俊许建明

【Author】 Xu Shuyun Ding Changhai Wei Wei Li Jun Xu Jinming Institute of Clinical Pharmacology,Anhui Medical University, Hefei 230032

【机构】 安徽医科大学临床药理研究所

【摘要】 对影响炎症免疫反应的药物的作用和作用机制进行了综述。从与炎症免疫性疾病有关的细胞凋亡、一氧化氮、T细胞亚群等角度提出了开发药物的新思路,并介绍了目前从细菌及其代谢物、细胞因子及其拮抗剂、神经内分泌物质和中药中研制疾病调修药的趋势。

【Abstract】 The medicine acting on inflammatory immune response involves three classes:steroidal antiinflammatory immunity drugs, non steroidal antiinflammatory immunity drugs and disease modifying drugs.This article reviews their pharmacologic actions and mechanisms,introduces some new thoughts about developing the disease modifying drugs according to the relation between inflammatory immune diseases and apoptosis, nitric oxide or T cell subtype, and discusses the trend of finding out new drugs from bacteria and their metabolite, cytokines and their antagonist, neuro endocrine substances and Chinese traditional herbs.

  • 【分类号】R979.5
  • 【被引频次】34
  • 【下载频次】262
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