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核苷研究Ⅸ3-甲硫基-7-氧代吡唑并(5,4-e)-1,2,4-三嗪核苷合成研究
Studies on Nucleosides IXSynthesis of Nucleosides of Pyrazolo(5,4-e)-l,2,4- triazine Derivatives
【摘要】 对3-甲硫基-7-氧代吡唑并(5,4-e)-1,2,4-三嗪的成苷反应进行了研究。当保护基为乙酰基时,生成的核昔β-体为主产物。当保护基为苯甲酰基时全部是β-体。端应构型用~1H NMR确定。在五元环中,顺位质子比反位质子裂分常数大。
【Abstract】 The ribonucleosides of pyrazolo (5,4 - e) - 1,2,4 - triazine derivatives were synthesized. The α,β- isomes were distinguished with 1H NMR. β - isomer was the major product in acetyl protected ribonucleosides. In benzoyl protected ribonucleosides, no α- isomer was formed. The JH1H2 of cis isomer was bigger than that of trans in five membered ring.
【关键词】 吡唑并-(5,4-e)-1,2,4-三嗪；
核苷；
合成；
【Key words】 pyrazolo(5； 4 - e) - 1； 2； 4 - triazine derivatives； ribonucleosides； synthesis；
【Key words】 pyrazolo(5； 4 - e) - 1； 2； 4 - triazine derivatives； ribonucleosides； synthesis；
- 【文献出处】 有机化学 ,Chinese Journal of Organic Chemistry , 编辑部邮箱 ,1997年03期
- 【分类号】O626
- 【被引频次】6
- 【下载频次】70