【摘要】 用1-芳酰基-2-硫代双脲与溴进行氧化成环反应制备了一系列新的5-芳酰氨基-2H-1，2，4-噻二唑-3-酮（2），而相应的1-芳酰基-2-硫代双脲（1）可以通过脲与酰基异硫氰酸酯加成制得，化合物1和2的结构通过元素分析、红外光谱和核磁共振波谱分析得到确证。对化合物2进行了抗菌活性筛选，结果表明化合物2a，2b，2f，对大肠杆菌和枯草芽孢杆菌有强的抑制作用。更多还原

【Abstract】 A series of new 5-aroylamino-2H-1,2,4-thiadiazol-3-ones（2）were synthesized from the corresponding 1-aroyl-2-thiobiurets by oxidative cydization with bromine.The needed 1-aroyl-2-thiobiurets（1）were obtained through the addition of urea to the corresponding aroyl isothiocyanates. The structures of 1 and 2 were identified by elemental analysis,IR and ¹H NMR.The compounds 2 were screened for their antifungal activity against Escherichia coli and Bacillus Subtilis at 0.1 mmol·1^-1.The results showed that 2a,2b and 2f exhibited strong inhibiting effect on Escherichia Coli andBacillus Subtilis.更多还原