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短期接触O3的小白鼠灌胃白果提取液对肝脏SOD活性的影响

Effect of O 3 and gingko solution on hepatic superoxide dismutase(SOD) activity in mice.

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【作者】 魏国勤戴建国陈景衡

【Author】 Wei Guoqing,et al.

【机构】 南京医科大学公共卫生学院卫生化学教研室

【摘要】 取体重15~20g雄性小白鼠,随机分为四组:白果组、白果+O3组、O3组、对照组,每组10只。白果组每天灌胃白果提取液10ml/kg;白果+O3组除每天灌胃白果提取液外,隔天放入O3染毒柜中;O3组每天灌胃生理盐水10ml/kg,并隔天放入O3染毒柜中;对照组在室内自由取食饮水。20天后处死小白鼠取肝脏测定超氧化物歧化酶活性,结果表明,O3组肝脏SOD活性明显高于对照组(P<0.05),其它各组之间无显著性差异。

【Abstract】 40 male mices were divided randomly into 4 groups of 10 each,the 1st gingko group,the 2nd gingko+ O 3 group,the 3rd O 3 group,the 4th control group.For the 1st group,mice were given gingko solution orally 10ml/kg per day.The 2nd group∶mice were given gingko solution orally 10ml/kg per day and were put in O 3 chamber every other day.The 3rd group∶mice were given physiological saline orally 10ml/kg per day and were put in O 3 chamber every other day.The 4th group∶mice had taken food and water freely in normal condition.After 20 days,SOD activity was determined on liver in 40 sacrified mice.The results showed that SOD activity on liver in O 3 group was remarkable higher than that of control group( P <0.05),whereas no remarkable changes among other groups.

【关键词】 肝脏臭氧(O3超氧化物歧化酶(SOD)
【Key words】 LiverO 3superoxide dismutase(SOD)
  • 【分类号】R135
  • 【被引频次】7
  • 【下载频次】79
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