【摘要】 本文报告了新生儿窒息呼吸衰竭35例血浆血管紧张素Ⅱ（AⅡ）、内皮素（ET）及醛固酮（ALD）的动态变化，20例正常新生儿作为对照组。结果显示：AⅡ急性期值明显高于缓解期（546．80±334．52：286．44±278．0ng／L）也高于正常新生儿对照组（384．99±311．13ng／L），P＜0．01。随着缺氧程度加重AⅡ活性增高，ET急性期值也高于缓解期和正常对照组，而且急性期ALD明显高于其它组。因此，我们建议在窒息和呼吸衰竭时早期检测AⅡ、ET及ALD为使用血管扩张药以增加脑血流改善缺氧缺血脑损害提供依据。更多还原

【Abstract】 Dynamic observation in measument of A Ⅱ ET and ALD in 35 cases of neonatal asphyxia and respiratory failure were reported. 20 cases of normal newborns were tested as controlled group. The results showed A Ⅱ value in acute stage was obviously higher than the convalesed stage (546. 80± 334. 52: 286. 44±278.0 ng/L)and also higher than the normal controlled group (384. 99±311. 13 ng/L) (P<0. 01). The increasement of A Ⅱ activity was related to the degree of hypoxia. The value of ET in acute stage was also higher that the convalesed stage and the normal controlled group. The value of ALD in acute stage was the highest htan all other group. Thus, For increasement of cerebral blood flow to improve hypoxic-ischemic brain injury to use vasodilatation durgs, early derection of A Ⅱ ET and ALD was suggested during asphyxia and respiratory failure.更多还原