【摘要】 模拟临床灌洗方法对染尘家兔进行大容量肺灌洗，并观察灌洗前后肺泡液中细胞及生化成分变化，为灌洗术的应用性评价提供科学依据。结果显示：灌洗后染尘动物肺泡液中除总磷脂，二棕榈酰卵磷脂（ＤＰＰＣ）外，细胞总数、蛋白质含量、乳酸脱氢酶（ＬＤＨ）、碱性磷酸酶（ＡＫＰ）活性均明显低于同期染尘未灌洗组，差异有显著性，此外还可洗出一定量的ＳｉＯ２粉尘，首次灌洗较第二次灌洗为多。提示：灌洗对矽肺发生发展有一定延缓作用，早期灌洗效果较好。更多还原

【Abstract】 Sterile saline was instilled into and aspirated from the lung of dust exposed rabbits in imitation of clinical method of the whole lung lavage. The changes of the biochemical and cellular components in alveolar fluid were observed before and after lavage with a view to providing evidence for the applicability of the method in the treatment of silicosis. The results showed that the number of cells, the protein content and the activities of both LDH and AKP were significantly lower than those of control group, except the total phospholipid and dipalmityl phosphatidyl choline (DPPC) in alveolar fluid after lavage. A certain amount of dust was also removed from lung with lavage. The wash out of SiO 2 from the first lavage was higher than that of the second lavage. It is suggested that lavage might delay the development of silicosis and be more effective in early stages of silicosis.更多还原