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进口、国产人用狂犬病疫苗免疫后中和抗体水平测定

Neutralizing Antibodies in Postexposure Treatment Persons Inoculated with Import or Native Rabies Vaccine

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【作者】 黄祖星陈爱贞梅重卿钟凌峭石亦人

【Author】 Huang Zhuxing,Chen Aizhen,Mei Zhongqing,et al (Health and Epidemic Prevention Station of Foshan City,Foshan 528000)

【机构】 广东省佛山市卫生防疫站

【摘要】 应用间接免疫荧光法(IFA)检测166例不同产地(国产、进口)人用狂犬病疫苗免后血清抗体水平,结果:国产苗抗体阳转率为95.42%,GMT为9.48,进口苗抗体阳转率为62.85%,GMT为4.35。经统计学处理,二者差异有非常显著性意义(X2=28.61P<0.005),初步提示了国产的(浓缩)原代地鼠肾组织培养狂犬病疫苗比某进口VERO细胞狂犬病疫苗免疫效果要好,是一种高效、安全、价格便宜的预防狂犬病免疫制品

【Abstract】 Comparison of native rabies vaccine and import rabies vaccine with IFA for antibody levels against rabies was studied.The seroconversion rates between them were 95.42% and 62.85% respectively and significant difference was found (x=28.61 p<0.005).The geometric mean titer (GMT) between them were 9.48 and 4.35.The results preliminary indicated that the rabies vaccine cultivated on primary hamster kidney cell,which produced by Wuhan Institute of biological products was more effective than import VERO cell rabies vaccine in immunization.

【关键词】 狂犬病疫苗抗体水平测定
【Key words】 Rabies vaccine Antibody levels Detection
  • 【文献出处】 微生物学免疫学进展 ,PROGRESS IN MICROBIOLOGY AND IMMUNOLOGY , 编辑部邮箱 ,1997年01期
  • 【分类号】R446.62
  • 【被引频次】6
  • 【下载频次】61
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