【摘要】 目的：研究肝癌患者外周血ＬＡＫ细胞活性。方法：作者应用ＭＴＴ法和间接免疫荧光法分别检测２７例肝癌、１９例肝硬化患者和２０例健康人外周血ＬＡＫ细胞活性和单个核细胞ＩＬ２Ｒ表达，结果：结果表明肝癌患者外周血ＬＡＫ细胞活性与ＩＬ２Ｒ表达均显著低于正常人和肝硬化患者（Ｐ＜０．００１）；肿瘤直径＞５ｃｍ的肝癌患者ＩＬ２Ｒ表达显著低于≤５ｃｍ者（Ｐ＜０．０５）；有门静脉癌栓者ＩＬ２Ｒ表达明显低于无门静脉癌栓者（Ｐ＜０．０５）；经化疗肝癌患者ＬＡＫ细胞活性及ＩＬ２Ｒ表达均较未经化疗者明显降低（Ｐ＜０．０５）。结论：结论提示ＬＡＫ细胞活性及ＩＬ２Ｒ表达可作为肝癌患者进行生物治疗的依据及其疗效观察指标更多还原

【Abstract】 Aim:to　study　on　the　lymphokine　activated　killer　cell　activity　in　patients　with　hepatocellular　carcincma.Method:The　LAK　activity　and　interleukin　2　receptor(IL2R)　expression　were　measured　in　patients　with　hepatocellular　carcinoma　(HCC,n=27),liver　cirrhose(LC,n=19)　and　control　groups(n=20).Results:The　results　showed　that　LAK　activity　and　IL2R　expression　were　markedly　decreased　in　HCC　groups　as　compared　with　that　of　LC　and　control　groups(P<0.001).It　was　suggested　that　the　disturbed　immune　function　in　HCC　patients　was　manifested　as　depressed　LAK　activity,deficient　IL2R　expession.The　HCC　patients　with　larger　tumors(>5cm　in　diameter)　showed　significantly　decreased　IL2R　expression　as　compared　with　that　of　smaller　tumors　(≤5cm　in　diameter,P<0.05);the　HCC　patients　with　tumor　thrombi　in　portal　branches　had　significantly　lower　IL2R　expression　than　that　without　tumor　thrombi(P>0.05).It　was　indicated　that　development　and　metastasis　of　HCC　might　be　associated　with　decreased　IL2R　expression　conclusions:The　LAK　activity　and　IL2R　expression　of　PBMC　in　HCC　patients　with　chemotherapy　were　significantly　depressed　as　compared　with　that　without　chemotherapy(P<0.05),this　demonstrated　that　chemotherapy　might　depress　the　immune　function　of　HCC　patients.更多还原