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221例良性胃病中幽门螺杆菌感染与癌胚抗原表达的研究
Study on infection With Helicobacter pylori and Expression of Carcinoembryonic antigen in 221 cases of benign gastric Disorders
【摘要】 胃镜取221例良性胃病的粘膜组织进行HE染色,Geimsa染色查Hp,CEA单克隆抗体免疫组化检查。结果:Hp感染率7738%(171/221),CEA阳性率3891%(86/221),肠化生(IM)和/或不典型增生(AH)发生率267%(59/221),在Hp阳性与阴性病变中,IM和/或AH发生率分别为3041%(52/171)及14%(7/50)(P<005);CEA的阳性率分别为4328%(74/171)及24%(12/50)(P<001)。提示Hp感染与胃的癌前病变的发生及CEA的表达相关
【Abstract】 ? The gastric biopsy specimens of 221 patients with benign gastric disorders were used for:HE staining,Geimsa staining to detect Helicobacter pylori(Hp),staining with monoclonal carcinoembryonic antigen(CEA) by the immunohistochemical ABC method.The results reveal that the prevalence of Hp infection was 77.38%(171/221);the positive rate of CEA was 38.91%(86/221);the incidence of intestinal metaplasia(IM) and/or atropical hyperplasia(AH) was 26.7%(59/221);the incidences of IM and/or AH in the lesions with and without Hp infection were 30.41%(52/171) and 14%(7/50)respectively(P<0.05).The CEA positive rates in the lesions with and without Hp infection were 43.28%(74/171) and 24%(12/50) respectively (P<0.01).Our results suggest that Hp infection is related to the high expression of CEA and the occurrence of gastric precancerous lesions.
【Key words】 Helicobacter pylori precancerous lesions carcinoembryonic antigen;
- 【文献出处】 胃肠病学和肝病学杂志 ,CHINESE JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY , 编辑部邮箱 ,1997年02期
- 【分类号】R573.1
- 【被引频次】2
- 【下载频次】27