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人参皂甙Rb₁、Rg₁、Re和Rh₁对细胞脱氢酶活性的影响

EFFECTS OF GINSENOSIDES Rb₁ ,Rg₁ ,Re AND Rh₁ ON DEHYDROGENASE ENAZYME ACTIVITY OF CELLS IN VITRO

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【Author】 Liu Ping, Ge Yingchun, Guo Yingjie, Yang Haibin,Wang Benxiang (Academy of Traditional Chinese Medicine and Materia Medico of Jilin Province,Changchun 130021)

【机构】吉林省中医中药研究院；长春中医学院附属医院新药研究开发中心；吉林省中医中药研究院长春 130021；长春 130021；长春 130021；

【摘要】应用显微分光光度术,定量地分析了人参皂甙Rb₁、Rg₁、Re、Rh₁对人胚肺成纤维细胞（2BS）和HeLa细胞脱氢酶活性的影响。结果表明,4种单体皂甙增加了高代龄2BS细胞内乳酸脱氢酶（LDH）,琥珀酸脱氢酶（SDH）,葡萄糖-6-磷酸脱氢酶（G-6-PDH）和丙酮酸脱氢酶（PVO）的活性,降低了HeLa细胞内这几种酶的活性。更多还原

【Abstract】 Using the microspectrophotometry , effects of ginsenosides Rb1, Rg1, Re and Rhi on dehy-drogenase enzyme activity in human fibroblasts from fetal lung and HeLa cells were analysed quantitatively. The results indicated that these ginsenosides increased these enzyme activities of Lactate dehy-drogenase (LDH), Glucoes-6-phosphate dehydrogenase (G-6-PDH) ,Succinate dehydrogenase (SDH) and Pyruvate oxidase(PVO)in high passage fibroblasts but decreased these enzyme activities in cancer cells.更多还原