【摘要】 为观察碳酸利多卡因硬膜外麻醉下行剖宫产对母婴的影响及血药浓度变化,选择择期剖宫产患者14例,ASA1～2级,分为试验组与对照组,每组各7例。硬膜外穿刺成功后.试验组注入2.2％碳酸利多卡因(pH6.63),对照组注入2％盐酸利多卡因(pH4.31),两组药液中均加入1/20万肾上腺素。观察给药后不同时期母体及新生儿脐动静脉血的药物浓度,同时记录硬膜外注药后起效时间、镇痛持续时间、阻滞节段与新生儿Apgar评分等临床指标。结果显示:试验组给药5mm后各时期母体及新生儿脐静脉血药浓度明显低于对照组(P<0.01),起效时间明显短于对照组(P<0.01)外,其他各项参数无明显差异。认为采用硬膜外麻醉行剖宫产手术,碳酸利多卡因可作为首选用药,更多还原

【Abstract】 To observe the effects and maternal and neonatal plasma concentration of lidocaine during epidural carbonated lidocaine for cesarean section,Fourteen patients(ASA 1~2 grade) were selected and divided into two groups. 2.2% carbonated lidocaine (pH 6. 63) were injected epidurally in group 1 (test group) and 2% hydrochloric lidocaine (pH 4-81) in group 2 (control group), both anesthetics were added with 1 : 200 000 adrenalin. The maternal plasma concentration of lidocaine at different times and neonatal blood concentrations were compared separately between the two groups. The onset time of analgesia, the time of continuous analgesia, blocking range and Apgar scores were recorded at same time. The results showed that the maternal plasma concentrations of lidocaine at different times and umbilical vein plasma concentration were markedly lower in group 1 than in group 2(P<0. 01). The onset time of analgesia were significantly shorter in group 1(3. 51 ± 0. 40)min than in group 2(5. 65± 0. 89)min (P<0. 01). The other clinical parameters in these two groups were similar (P>0. 05). The findings indicated that the carbonated lidocaine was safe and effective, and could be used in obstetrical operations.更多还原