【摘要】 选择12例ASAI～Ⅱ级的择期胆囊手术病人,术中采用异丙酚混合液维持麻醉,连续监测脑干听觉诱发电位(BAEP),并每隔10分钟测异丙酚血药浓度一次。结果显示:1.脑干听觉诱发电位Ⅰ～Ⅴ波潜伏期于插管时活跃,术中处于平台期,拔管后潜伏期(AMP)恢复至术前水平并逐渐缩短。2.术中BAEPⅠ～Ⅴ波如果有3个以上波的AMP缩短,并Ⅰ～Ⅴ波峰间距缩短,显示病人麻醉减浅,应及时加深麻醉,防止术中知晓。3.异丙酚血药浓度与BAEPⅠ～Ⅴ波AMP改变呈正相关,术中异丙酚血药浓度呈平行变化,为2.6mg/L左右,苏醒时异丙酚血药浓度<1mg/L4.BAEP监测可有效防止全麻术中知晓的发生。更多还原

【Abstract】 Twelve patientsCASA Ⅰ~Ⅱ) who underwent elective cholecystectomy were studied. The anesthesia was maintained with propofol solution,and the brainstem auditory evoked potentials (BAEP) were recorded continously. The plasma concentration of propofol were measured every 10 minutes. The results showed :1. The latency period(AMP)of wave I~V increased significantly when intubation. The BAEP waves remained flat during surgery while in AMP restored to preoperative levels at periextuba-tion. 2. It reflected that the patients required more deep anesthesia to prevent awareness when the AMP shortened in more than 3 waves and the peak latencies (wave Ⅰ~Ⅴ) shortened. 3. The plasma concentration of propofol were positively related with BAEP. The concentration of propofol remained stable during surgery(2. 6mg/L) ,and decreased to Img/L after recovery. 4. The monitoring of BAEP may effectively prevent awareness during general anesthesia.更多还原