【摘要】 为了探讨推拿镇痛的作用机理,本文采用推挽灌流法直接动态观察了清醒家兔PAG灌流液中β-END及单胺类物质的释放变化,并设立轻、重手法及对照组。结果表明推拿轻手法镇痛时,PAG灌流液中β-END含量升高,NE、DA、及其代谢产物DOPAC含量均降低;重手法镇痛时,NE、DA及DOPAC含量均明显下降,β-END含量亦有所下降,两手法皆能提高家兔痛阈。中央灰质在灌流心得安后,两手法皆不能提高痛阈。由此提示推拿镇痛途径之一是通过降低PAG中的DA而起作用,β受体亦参与此作用,且轻重手法推拿镇痛机制存在差异。更多还原

【Abstract】 Tn order to approach the machenisrn of massage analgesia, the article observed the changes of (3-END and released monoamine-subtstance in rabbits’ PAG perfusion liquid. The results showed that (3-END increased, contents of NE^DA and DOPAC decreased as analgesia by mild massage therapy; the contents of NE^DA and DOPSAC decreasde significanly, content of J3-END decreased as analgesia by heavy massage therapy, both massage therpies could raise rabbits’ pain threshold. Both mild and heavy massage therapies couldn’t raise the pain threahold after perfusion propanlol.All these suggested that one of the mechanism of massage analgesia maybe decrease the contents of NE and DA, etc. meanwhile {3-receptor participated in the effect, and the mechanisms of mild and heavy massage therapy were difference.更多还原