【摘要】 采用放射免疫法动态观察40例脑梗塞（CI）患者血浆内皮素（ET）、血管紧张素Ⅱ（AⅡ）、醛固酮（ALD）及降钙素基因相关肽（CGRP）的变化。结果发现，在CI整个病程中，血浆ET、AⅡ、ALD均高于正常对照组（P＜0．01或＜0．05），而CGRP低于正常对照组（P＜0．01）。CI病程3d及10～14d，血浆ET、AⅡ、CGRP、ALD均高于病程25～28d及脑动脉硬化组（P＜0．01或＜0．05），脑动脉硬化组与病程25～28d者之间无显著性差异（P＞0．05）。血浆ET、AⅡ、ALD及CGRP水平与病程、病情程度及是否伴有高血压、糖尿病有关。更多还原

【Abstract】 The airn of this study was to investigate the relation of cerebral infarction (CⅠ) and its complications with plasma endothelins (P-ET), angiotensin Ⅱ (p-A Ⅱ), aldosterone (P-ALD) and calcitonin generelated peptide (p-CGRP). The experimental patients were divided into 3 groups: cerebral infarction group,atherosclerosis group and normal controls. P-ET, P-A Ⅱ, P-ALD and P-CGRP levels fo CⅠ patients were determined on 3rd day, 10~14th days and 25~ 28th days after onset, also for atherosclerosis patients and normal controls. The results showed that the P-ET. P-A Ⅱ and P-ALD levels of CⅠ patients in total process were higher than those of the normal controls, but the P-CGRP levels were lower. The P-ET and P-A Ⅱ levels of CⅠ patients with hypertension were higher than those without hypertension, but the P-CGRP levels were lower. The P-ET and P-A Ⅱ levels of CⅠ patients with diabetes were higher than those without diabetes. The P-ET, P-A Ⅱ and P-CGRP levels on 3rd day after onset of CⅠ patients in serious state of the illness were higher than those in light and moderate states. This study suggests that ① cerebral infarction is correlated with P-ET, P-A Ⅱ, P-ALD and P-CGRP: ② hypertension is correlated with P-ET, P-A Ⅱ and P-CGRP: ③ diabetes is correlated with ET and A Ⅱ: ④ in patients on 3rd day after onset, the P-ET, P-A Ⅱ and P-CGRP levels can roughly reflect the state of the illness.更多还原