【摘要】 研究观察了家兔在高胆固醇饲料的喂养下，可能诱发红细胞膜的脂质过氧化损伤。在喂养2个月前后的比较中，发现血浆总胆固醇（PTC）和低密度脂蛋白胆固醇（PLDL-C）显著升高;红细胞膜低密度脂蛋白胆固醇（MLDL-C）和共轭双烯（MCD）及红细胞丙二醛（RMDA）明显上升:MLDL-C由（3.4±1.9）μmol／g上升到（5.9±1.8）μmol／g;MCD（140.6±54.7）μmol／g上升到（.291.8±140.2）nmol／g;RMDA（14.3±1.9）nmol／g上升至（17.4±2.3）nmol／g，差异有非常显著性意义（P＜0.01）。但红细胞超氧化物歧化酶（RSOD）和膜流动性（LFU）显著下降，RSOD由（1751.0±265.7）U／g下降到（1321.6±343.6）U／g;LFU由1.8±0.8下降到0.8±0.3（P＜0.01）。结果显示，高胆固醇饲料不仅引起高胆固醇血症，而且可以诱导红细胞膜生物化学和生物物理学的一系列改变。更多还原

【Abstract】 We observed lipidperoxidate injury to rabbits’ erythrocyte membranes induced by hypercholesterol food for two months. By comparing the status be fore and after the feeding, the results showed that plasma TC and LDL-C were significantly increased; erythrocyte membranes LDL-C, CD and erythrocyte MDA were significantly increased (3. 4 ±1. 9 ) μmol/g vs (5. 9 ±1. 8)μpmol/g, (140. 6 ± 54. 7 ) nmol/g vs (291. 8 ±140. 2 ) nmol/g, (14. 3 ± 1. 9) nmol/g vs (17. 4 ± 2. 3 ) nmol/g, P＜0.01,respectively; erythrocyte SOD and LFU were significantly decreased (1 751. 0±265. 7) U/g vs (1 321. 6± 343. 6) U/g, 1. 8± 0. 8 vs o. 8±0.3, P＜0.01, respectively. The results suggest hypercholesterol food induces a series of changes in biochemistry and biophysics of erythrocyte membranes.更多还原