In this paper, 38 cases of middle and malignant thoracic cavity store fluid were treated by the microbe suppprsession actoome BC369. The results showed that complete response rate (CR) is 92. 1 % (35/38); the partialresponse rate (PR) is 7. 9 % (3/38 ), total response rate (CR + PR) is 100% (38/38); It was Suggested thatBC369 is effected to the malignant thoracic cavity store fluid.