【Abstract】 Normal human very low density lipoprotein (VLDL) can be separated into two subfractions on Heparin-Sepharose 6B chromatography. one is called ApoE-poor VLDL and the other, ApoE-rich VLDL. They are different in compositions. Mouse peritoneal macrophages (MPM)were incubated with ApoE-poor VLDL or ApoE-rich VLDL at same concentrations for 24 hours.Increases of ApoE mRNA contents in both groups were higher than that in control and the highestApoE mRNA content was seen in MPM incubated with ApoE-poor VLDL. The results suggestthat VLDL can stimulate ApoEgene expression in MPM and the ApoE-poor VLDL exhibits morepronounced effect. It was predicted that the ApoE secreted by MPM might incorporate intoVLDL, especially the ApoE-poor VLDL, and enhance the uptake of these lipoproteins by MPM orother local cells via ApoE mediated receptor pathways.更多还原