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增殖细胞核抗原在鼻咽癌组织中的表达及其临床意义
The Expression of PCNA in Nosopharyngeal Carcinoma and Its Clinical Significance
【摘要】 目的:探讨鼻咽癌(NPC)组织PCNA的表达与其临床进展、病理组织分型的相互关系。方法:用免疫组化S-P法检测113例NPC和25例鼻咽慢性炎的PCNA表达。结果:103例NPC和3例鼻咽慢性炎呈PCNA阳性。NPC呈PCNA低增殖频率者,倾向于Ⅰ、Ⅱ期临床分期(87.1%)及无淋巴结转移(70.96%)。高增殖频率者,倾向于Ⅲ、Ⅳ期临床分期(82.1%)及有淋巴结转移(79.49%)。增殖频率与NPC临床分期及淋巴结转移有非常显著差异(P<0.01)。结论:反映细胞增殖的PCNA增殖频率与临床分期、淋巴结转移密切相关,可作为NPC进展的重要参考指标。
【Abstract】 To explore the relationship of the expression of PCNA to clinical stage, lymph node metastasis and pathological histological classification. The S - P immunohistochemical method was adopted for 113 cases of NPC and 25 cases of chronic nosopharyngeal inflammation in PCNA. 103 cases of NPC and 3 cases of chronic nosopheqngeal inflammation werepositive for PCNA. The low - proliferative rate of PCNA in NPC tended to Ⅰ or Ⅱ of clinicaI stages (87. 1 % ) and non - metastasis lymph node (70.96) .The high - proliferative rate tended to Ⅲ or Ⅳ (82. 1 % ) and the lymph node metastasis (79.49% ). It Showed a remarkable difference among the proliferative frequency to itsclinical stages of NPC and lymph node metastasis (P < 0.01 ). Conclusion The positive rate of PCNA proliferation of cells is aclose association to its clinical stages and lymph node metastasis, it was important refered index which regarded as progression of NPC.
【Key words】 nosopharyngeal carcinoma proliferation cellnuclear antigen immunohistochemistry;
- 【文献出处】 汕头大学医学院学报 ,JOURNAL OF SHANTOU UNIVERSITY MEDICAL COLLEGE , 编辑部邮箱 ,1997年03期
- 【分类号】R739.6
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