【摘要】 实验用乌拉坦麻醉、箭毒制动、人工呼吸的大鼠。将谷氨酸注入岛皮层（INS）以及将P物质（SP）注入外侧下丘脑／穹窿周围区（LH／PF）或室旁核均引起升压反应。INS-升压反应可被中央杏仁核（AC）内预先注射普鲁卡因或谷氨酸二乙酯（GDEE，谷氨酸拮抗剂）以及LH／PF内注射[D－Pro2，D-Phe7，D－TrP9]（DPDPDT，SP拮抗剂）明显衰减，但LH／PF内GDEE预处理对该反应无明显影响。室旁核内预先注射普鲁卡因或DPDPDT也使INS-升压反应显著减小。鉴于我们的其它工作曾显示LH／PF和室分核都介导AC-升压反应，上述结果提示：INS通过兴奋AC（谷氨酸受体）进而激活LH／PF和室旁核（SP受体），是其升压反应机理的重要组成部分。更多还原

【Abstract】 In urethane-anesthetized, tubocurarine-immobilized and artificially ventilated rats, glutamate (Glu) injection into the insular cortex (INS) and substance P injection into the lateral hypothalamus-perifornical region (LH/PF) or nucleus paraventricularis (NPV) caused pressor responses. Preinjection of procaine or glutumate diethyl ester (GDEE, a glutumate antagonist) bilaterally into the nucleus amygdaloideus centralis (AC) and [D- Pro2, D- Phe7, D- Trp9] - substance P (DPDPDT, a substunce P antugonist), but not GDEE, into the LH/PF markedly attenuated the pressor response induced by glutamate injection into the INS. Procaine or DPDPDT preinjection into the NPV also reduced the INS-pressor response. Since the LH/PF and NPV were found to mediate the AC-pressor response, the above results suggest that the INS- pressor response is the final outcome of activation of AC (Glu-receptor) -LH/PF and NPV (SPreceptor) system.更多还原