【摘要】 本文研究了几种免疫增强剂对动物睡眠的影响，并分析了免疫系统影响睡眠的物质基础。异丙肌苷、转移因子、胞壁酰二肽（ＭＤＰ）在增强动物免疫功能的同时，均能延长动物的慢波睡眠时间。以ＭＤＰ为代表观察了肿瘤坏死因子（ＴＮＦ）在免疫系统影响睡眠过程中的中介作用。结果表明，ＴＮＦ可促进家兔睡眠；ＭＤＰ可通过促进星形胶质细胞中ＴＮＦ－αｍＲＮＡ的表达，增加ＴＮＦ的合成与释放，从而提高脑内ＴＮＦ水平；ＴＮＦ单克隆抗体可部分阻断ＭＤＰ促进睡眠的作用，这些结果肯定了ＴＮＦ在免疫系统与睡眠之间的中介作用。进一步的研究表明，ＴＮＦ促进睡眠的机制是提高脑内５－ＨＴ的更新率，从而增强５－ＨＴ能神经的功能。更多还原

【Abstract】 The influence of three immunoenhancers on animal sleep and their mechanism was studied. Isoprinosine, transfer factor and muramyl dipeptide(MDP) could promote animal immune function, and prolong the sleeping time of mice and rabbits. Tumor necrosis factor(TNF), an immune cytokine, could prolong animal sleep; MDP could increase the synthesis and secretion of TNF from cultured mice astrocytes by promoting the expression of TNFα mRNA, resulting in an increase of TNF level in mice brains; monoclone antibody of TNF could partly antagonize the promoting effect of MDP on rabbits sleep. These results suggest that TNF is an important mediator in the influence of immune system on sleep. TNF could increase the turnover rate of 5 HT in mice brains, which may be one of the mechanisms of TNFs promoting effect on sleep.更多还原