【摘要】 检测哮喘发作期（35例）、稳定期（18例）及正常对照组（28例）血清IL-6、IL-8、TNF-α和IFN-α水平。结果表明哮喘发作期IL-6、IL-8、TNF-α水平明显增高,而IFN-α显著降低;至稳定期血清IL-6、IL-8、TNF-α恢复到对照组水平,唯IFN-α仍低于正常儿。血清THN-α与IL-6、IL-8、IFN-α间存在正相关关系。提示哮喘患儿存在多种细胞因子产生和释放异常。细胞因子网络失调可能是哮喘发病的分子生物学基础。更多还原

【Abstract】 Serum Levels of IL-6, IL-8, TNF-a, IFN-a were measured in children with attacks of asthma (35 cases)- under stable condition (18 cases) and controls (28 cases). Increase of IL-6. IL-8 and TNF-a and decrease of IFN-a were found in patients with attacks. Company with asthma remission, the levels of IL-6, IL-8 and TNF-a were decreased to the levels of controls, and that of EFN-a was still below the levels of health children. The positive relationship of TNF-a with IL-6, IL-8 and TNF-a were detected in patients with attacks. These results suggest that there might exist abnormalities in the productions and releases of many cytokines in cases with asthma, and the imbalances on the cytokine networks might be the molecular-biological basis in the pathogenesis of asthma.更多还原