【摘要】 本文在空肠弯曲菌（CJ-S131）免疫诱导的小鬼SLE样综合征模型上,观察了T细胞接种（T CellVaccination,TCV）的预防和治疗作用。用于 TCV的细胞为 CJ-S131预致敏的同系小鼠 T细胞。结果显示TCV可明显地抑制CJ-S131诱导的特异性迟发型超敏反应,相反却显著地增强抗dsDNA抗体和抗外膜蛋白抗体生成。因此TCV对SLE样小鼠没有预防及治疗作用。本文对此现象进行了讨论。更多还原

【Abstract】 T cell vaccination (TCV) is a promising method to treat or prevent some autoimmune diseases mediated by T lymphocyte such as adjuvant arthritis(AA) andexprimental autoimmune encephalomyelitis (EAE). In this study, We investigated the function of TCV on SLE-like mice which were induced by immunizing with Ca-mpylobacter jejuni (CJ-S131). The syngeneic lymph node cells, primed by CJ-S131 in vivo and activated by Con A in vitro, were used as T cell vaccine. The results sho wed that TCV is unable to cure or prevent SLE-like syndrome. Although the delayed type hypcrsensitivity against CJ-S131 was significantly inhibited, TCV markedly enhanced the anti-dsDNA antibody and membrane protein of CJ-S131 antibody production. Therefore, TCV may induce immune deviation.更多还原