【摘要】 采用气相色谱法分析151名胆固醇结石（CS）病人和256名正常人血清胆汁酸，以及90份配对的胆汁和血清胆汁酸。结果发现CS病人血清脱氧胆酸（DCA）含量高于正常人；DCA／鹅脱氧胆酸（CDCA）比值较正常人增高近1倍。胆汁DCA相对浓度与胆固醇饱和指数成正相关。血清DCA含量和DCA／CDCA比值的升高是CS患者胆汁酸变化的特征和监测指标。更多还原

【Abstract】 Analysis of bile acids both in bile and serum was done with gas chromatography in 2groups: cholesterol gallstone (CS) group (n=151) and control group (n=256). Bile acids and lipids were also studied in 90 matched bile and serum. The results showed that the amount of serum deoxycholic acid (DCA) was 0.955±0.078 μmol/L in CS group which was more than that of control group (0.696±0.047 μmol/l), P<0.01. The ratio of DCA/chenodeoxycholic acid(CDCA) was 1.76±0.30in CS group which was about 2 times that in control group (0.92±0,14). The mole percent of DCA in bile was positively related to cholesterol saturation index (CSI) (P<0.01) and the mole percent of CDCA in bile was negatively related to CSI (P=0.01). The correlation was present between the mole percent of DCA, CDCA and cholic acid in bile and those in serum. This study suggests that DCA is a lithogenic bile acid and the increased amount of DCA or the ratio of DCA/CDCA in serum may beone of the features of CS patients.更多还原