【摘要】 研究了１，２－二甲基－３－羟基－４－吡啶酮（ＤＨＰＯ）尿铝促排及其与维生素Ｃ（Ｖｃ）、利尿剂美司那（二巯基乙烷磺酸钠）的协同排铝作用。结果表明，ＤＨＰＯ可显著增加尿排量（Ｐ＜０．００１），ＤＨＰＯ加Ｖｃ和ＤＨＰＯ加美司那组的尿铝排量与ＤＨＰＯ组相似，但尿铝排出的峰值发生改变，组间无显著差异。更多还原

【Abstract】 The effects of 1,2dimethl3hydroxypyrid4one(DHPO)alone or in combination with ascorbic acid and Mesna on urinary Aluminium excretion were studied.The results showed that DHPO(ig)significantly increased urinary Al excretion(P<0.001).DHPO+Vc and DHPO+Mesna were found to have comparable potency,but the Al excreting peak times were changed.The significant difference were not found among groups of DHPO+Vc,DHPO+Mesna and DHPO.更多还原