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DTPA双酯Gd(Ⅲ)配合物的合成及其弛豫率

SYNTHESIS AND RELAXIVITY OF DTPA DIESTER Gd(Ⅲ) COMPLEXES

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【作者】 柏正武卓仁禧

【Author】 Bai Zhengwu and Zhuo RenXi (Department of Chemistry, Wuhan University, Laboratory of Biomedical Polymer Materials of the State Education Commission, Wuhan 430072)

【机构】 武汉大学化学系!国家教委生物医用高分子材料开放实验室武汉430072

【摘要】 二乙三胺五乙酸双酐与甘醇单醚反应,得到含多氨基多羧基双酯配体,配体与GdCl36H2O反应生成非离子配合物.配体及配合物用IR、1HNMR和元素分析进行了表征,并测试了配合物的驰豫率,其中3种配合物的弛豫率比已用于临床诊断的Gd(DTPA)强,

【Abstract】 Polyaminocarboxylate ligands were synthesized by the reaction of diethylenetriaminepentaacetic dianhydride with glycol monoether, and their Gd(Ⅲ) complexes were also prepared. The structures of the ligands and complexes were confirmed by IR, 1H NMR spectra and elemental anaJysis. The relaxivity of these Gd(Ⅲ) complexes were investigated and the data indicated that three of them showed higher relaxivity as compared to Gd(DTPA).

【基金】 国家“863”高科技项目
  • 【文献出处】 波谱学杂志 ,CHINESE JOURNAL OF MAGNETIC RESONANCE , 编辑部邮箱 ,1997年04期
  • 【分类号】O627
  • 【被引频次】8
  • 【下载频次】154
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